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Lorazepam can be used in conjunction with antidepressant therapy to strengthen, complete, and partially accelerate the effect. It has a positive effect on mood while also protecting against psychic stress.
The recommended dose varies depending on the type and severity of the disease being treated; most patients respond to two or three 1 milligram doses per day, with 2.5 milligram tablets being used in the most severe cases. It is not recommended that the elderly patient take more than 2 milligrams per day.
It is recommended that all patients undergoing therapy receive a higher dose in the evening in order to get a good night's sleep and to make the most of the daytime hours by favoring daily activities.
Lorazepam's plasma concentration is reached within two to three hours of administration, and the drug's half-life is about 14 hours. Lorazepam is available in three forms: solution, tablet, and injectable.
When lorazepam is taken in conjunction with alcoholic beverages, the sedative effect is amplified. The prescriber must carefully assess the interaction with other psychotropic drugs.
When combined with opioids, alcohol, or other CNS-acting drugs like neuroleptics, hypnotics, antidepressants, or antiepileptics, it can cause depressive effects in the central nervous system (CNS).
It manifests as drowsiness, dysarthria, mental confusion, and coma states in varying degrees of CNS depression. Overdose problems are most common when alcohol and/or other medications are combined.
In order to induce vomiting (within one hour of dosing) in alert patients or to perform gastric lavage with airway protection in unconscious patients, it may be necessary to induce vomiting (within one hour of dosing). To reduce absorption, activated charcoal should be used.
Flumazenil, a commercially available antidote, can be used to block the binding of benzodiazepines to the GABA receptor in cases of acute poisoning.
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