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What is Oxycontin and when is it used?

Oxycontin is a pain reliever for the treatment of persistent, medium or severe pain. Contains the active ingredient oxycodone. After taking Oxycontin, the active ingredient is slowly released in the gastrointestinal tract and enters the bloodstream. For this reason, the pain-relieving effect lasts for about 12 hours.

When Oxycontin can't be taken?

• If you are hypersensitive (allergic) to the active substance oxycodone or to one of the auxiliary substances,
• in case of severe respiratory impairment, such as in severe bronchial asthma or in case of severe chronic narrowing of the airways,
• in case of increase in right heart pressure as a result of pulmonary hypertension (cor pulmonale),
• in case of intestinal paralysis (paralytic ileus),
• if you are breastfeeding.

When is caution required in the administration of Oxycontin?

• In case of severe pulmonary insufficiency, in case of hepatic or renal insufficiency,
• in case of thyroid insufficiency,
• in case of insufficiency of the adrenal glands (Addison's disease),
• in case of mental disorders caused by alcohol or intoxication, alcoholism or severe reactions to alcohol withdrawal,
• in case of gallstones or other biliary tract diseases,
• in case of inflammation of the pancreas,
• in case of bowel obstruction or inflammatory bowel disease,
• in case of an enlarged prostate,
• in case of arterial hypotension or hypertension or pre-existing cardiovascular disease,
• in case of head injuries, epilepsy or tendency to seizures,
• when using medicinal products from the group of monoamine oxidase inhibitors (MAOIs); the intake of Oxycontin is not indicated concomitantly with a MAOI-based therapy or within 14 days following the discontinuation of such therapy.

In people of advanced age or physically weak, side effects are more likely to occur. So be especially cautious.

If you have not recently taken any other pain reliever similar to morphine, Oxycontin 80 mg is not indicated to start therapy as in this case the degree of effectiveness could lead to respiratory paralysis (respiratory depression) with a fatal outcome.

In case of long-term use of Oxycontin, tolerance may occur. In this case, a higher dose may be required to achieve the desired pain-relieving effect.

Long-term use of Oxycontin can also cause physical dependence. Withdrawal symptoms such as agitation, bouts of sweating, and muscle aches may occur when therapy is stopped suddenly. If you no longer need therapy, you should gradually reduce the daily dose in consultation with your doctor.

Oxycontin should not be used as a first-line medication in the treatment of long-term pain caused by benign diseases. Oxycontin is to be used as part of a broad therapeutic program including other medications and treatments.

The active ingredient oxycodone has a risk of abuse similar to that of all other potent pain relievers similar to morphine. There is the possibility of developing a psychic addiction. In case of current or previous abuse of alcohol, drugs or medicaments it is necessary to avoid taking Oxycontin.

If you have surgery, tell your doctors that you are taking Oxycontin.

Prolonged use of morphine-like pain relievers such as Oxycontin can lead to reversible hormonal changes such as decreased function of the adrenal cortex with symptoms such as nausea, vomiting, loss of appetite, fatigue, weakness, dizziness or arterial hypotension or decreased function of the sexual organs with symptoms such as decreased libido, erectile dysfunction or amenorrhea.

Some medications can increase the likelihood of side effects (in particular impaired respiratory function (respiratory depression), hypotension, sleepiness and / or reduced alertness), which in severe cases can lead to profound drowsiness, coma and death :

• other morphine-like pain relievers (opioids),
• sleeping pills and tranquilizers (such as benzodiazepines),
• some medications for allergies, motion sickness or nausea,
• some medications for depression (including hypericum) and psychosis,
• some medicines to treat seizures and certain types of pain (carbamazepine, phenytoin),
• some antibiotics (e.g. clarithromycin, rifampicin, gabapentin, pregabalin),
• some medicines for fungal infections (mycosis) (e.g. ketoconazole) or for the treatment of HIV (e.g. ritonavir),
• some medicines against heartburn and gastroduodenal ulcer (e.g. cimetidine),
• muscle relaxation medications,
• medicaments for Parkinson's disease.

Tell your doctor or pharmacist immediately if you are using any of these medicines and strictly adhere to the dosage recommended by your doctor. It may be helpful to ask family and friends to tell you if they notice the signs and symptoms mentioned above in you. If these symptoms occur, please contact your doctor.

If you take Oxycontin together with certain medicines that decrease the blood's clotting ability (coumarin derivatives), the blood may clot more quickly or slower.

Do not drink alcohol while taking Oxycontin. Drinking alcohol while taking Oxycontin can lead to excessive sleepiness and increase the risk of severe side effects such as shallow breathing and the consequent risk of respiratory arrest and loss of consciousness, which in severe cases can lead to coma and to death.

It is recommended that grapefruit and grapefruit juice be avoided while taking Oxycontin.

The risk of side effects is increased if you use certain medications for depression (eg citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine). These medications can affect the effect of oxycodone and symptoms such as: involuntary and rhythmic muscle contractions, including eye twitching (twitching of the muscles that control eye movements), agitation, excessive sweating, involuntary tremor, sharp reflexes, increased muscle tension or body temperature above 38 ° C. Tell your doctor if you notice these signs.

The retard tablets must be swallowed whole and must not be divided, chewed or crushed. If the tablets are split, chewed or crushed, they release the active ingredient faster and a lethal dose of oxycodone may be taken.

Oxycontin retard tablets should by no means be dissolved and injected (e.g. into a blood vessel) in an attempt to abuse them, as this can have very serious health consequences and even cause death.

The retard tablet, after having released all the active ingredient, does not dissolve completely in the intestine, and therefore it is possible to find residues in the faeces. This does not lead to any reduction in the effectiveness of the preparation.

Taking Oxycontin can give positive results in case of doping controls.

This medicine contains lactose. Therefore, consult your doctor before taking Oxycontin if you know you have an intolerance to certain sugars. People with rare hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption should not take Oxycontin.

Oxycontin can reduce the ability to react, the ability to drive a vehicle and the ability to use tools or machines! So ask your doctor if you can drive a car, use machines and perform dangerous work.

Tell your doctor or pharmacist, just in case

• suffer from other diseases
• suffer from allergies or
• takes other medicines (even if purchased on his own initiative) or applies them externally.

Can Oxycontin be taken while pregnant or breastfeeding?

If you are pregnant or wish to have a baby, please tell your doctor, who will make a decision on using Oxycontin. Prolonged use of Oxycontin during pregnancy can cause withdrawal symptoms in the newborn.

If Oxycontin is taken during childbirth, it can cause slowed breathing (respiratory depression) in the newborn.

If you are breastfeeding, you should not take Oxycontin.

How to use Oxycontin?

Always take Oxycontin following your doctor's instructions carefully. If you are unsure, ask your doctor or pharmacist for clarification.

Oxycontin retard tablets should be taken with a sufficient amount of liquid (½ glass of water) with meals or between meals, in the morning and in the evening, always at the same time (e.g. in the morning at 8 and in the evening at 20). You must not split, chew or crush the retard tablet.

The usual starting dose is one 10 mg Oxycontin retard tablet every 12 hours. Your doctor will adapt the dosage to the intensity of the pain and the individual reaction.

Tell your doctor if you get any pain between taking Oxycontin. Your doctor may prescribe a quick-release pain reliever to treat sudden pain during therapy.

If you have taken more Oxycontin than prescribed, you should inform your doctor immediately.

If you forget to take a dose, you can take the missed tablet right away if your next regular intake is more than 8 hours later. You can then stick to your regular schedule. If the next intake is expected within less than 8 hours, still take Oxycontin but postpone the next intake by 8 hours. Under no circumstances should you take the double single dose.

Do not stop taking Oxycontin without first talking to your doctor. If the therapy is no longer indicated, it is advisable to gradually reduce the daily dose to avoid the appearance of withdrawal symptoms.

The use and safety of Oxycontin in children and adolescents under 18 have not been investigated so far.

Do not change the prescribed dosage on your own initiative. If you think that the action of the medicine is too weak or too strong, talk to your doctor or pharmacist.

What side effects can Oxycontin have?

Taking Oxycontin can very often cause constipation. A diet rich in fiber and a sufficient amount of fluids can counter this effect. However, it is often necessary for your doctor to prescribe a laxative in addition.

Nausea and vomiting are very common, particularly at the start of therapy. If you feel nauseous or need to vomit, please tell your doctor who may prescribe an anti-nausea or antiemetic medicine.

After taking Oxycontin, the following side effects may additionally occur:

Sense of dizziness, headache, drowsiness, itching.

Loss of appetite, fear, confusion, insomnia, nervousness, disturbed thinking, depression, tremor (of the muscles), inertia, impaired respiratory function, breathlessness, stomach pains, diarrhea, dry mouth, digestive disturbances, sweating, rash, weakness, tiredness.

Hypersensitivity reactions, dehydration, mood changes, agitation, euphoria, hallucinations, drug addiction, memory impairment, seizures (especially in people with epilepsy or predisposed to seizures), increased muscle tension, involuntary muscle spasms, numbness or other symptoms of decreased sensitivity of the skin, speech disturbances, narrowing of the pupils, disturbed vision, dizziness, palpitations, dilation of blood vessels, fainting, slowed breathing (respiratory depression), swallowing disorders, hiccups, belching, flatulence, bowel obstruction, taste disturbances, increased liver values, dry skin, urine retention, decreased sex drive, erection disturbances,decreased function of the sexual organs, chills, withdrawal symptoms, fluid retention (edema), general malaise, thirst, tolerance to medication

Drop in blood pressure, itchy rash (hives).

Acute general allergic reactions, increased sensitivity to pain (hyperalgesia), aggression, accelerated pulse, dental caries, biliary stasis, and absence of menstruation have also been reported.

In the event of a presumed overdose, the doctor must be informed immediately, who will take the necessary countermeasures. Signs of overdose are narrowing of the pupils, extreme slowing of breathing, low blood pressure, narcosis-like state.

Respiratory paralysis is the most serious danger related to overdose.

If you notice any side effects, please contact your doctor or pharmacist, especially if they are side effects not described in this leaflet.

The medicinal product should not be used beyond the date indicated with "EXP" on the container.

Store at room temperature (15-25 ° C). Keep out of the reach of children.

Once the treatment is complete, take the remnant of the medicine to a collection point (doctor's office, pharmacy) so that it can be disposed of correctly.

Your doctor or pharmacist, who have detailed professional information, can give you further information.

What does Oxycontin contain?

Oxycodone hydrochloride

1 Oxycontin 5 mg retard tablet contains 5.00 mg of oxycodone hydrochloride (corresponding to 4.48 mg of oxycodone).

1 Oxycontin 10 mg retard tablet contains 10.00 mg of oxycodone hydrochloride (corresponding to 8.97 mg of oxycodone).

1 Oxycontin 20 mg retard tablet contains 20.00 mg of oxycodone hydrochloride (corresponding to 17.93 mg of oxycodone).

1 Oxycontin 40 mg retard tablet contains 40.00 mg of oxycodone hydrochloride (corresponding to 35.86 mg of oxycodone).

1 Oxycontin 80 mg retard tablet contains 80.00 mg of oxycodone hydrochloride (corresponding to 71.72 mg of oxycodone).

Oxycontin retard tablets contain povidone K30, ammonium methacrylate copolymer (type B), sorbic acid, triacetin, stearyl alcohol, talc, magnesium stearate, hypromellose, macrogol 400 and titanium dioxide (E 171) as auxiliary substances.

1 Oxycontin 5 mg retard tablet also contains 77.30 mg lactose monohydrate and brilliant blue FCF (E 133).

1 Oxycontin 10 mg retard tablet also contains 69.25 mg lactose monohydrate and hydroxypropylcellulose.

1 Oxycontin 20 mg retard tablet also contains 59.25 mg lactose monohydrate, polysorbate 80 and red iron oxide (E 172).

1 Oxycontin 40 mg retard tablet also contains 35.25 mg lactose monohydrate, polysorbate 80 and yellow iron oxide (E 172).

1 Oxycontin 80 mg retard tablet also contains 78.50 mg lactose monohydrate, hydroxypropylcellulose, indigo carmine (E 132) and yellow iron oxide (E 172).